Jasinska Anna J, Zelaya Ivette, Service Susan K, Peterson Christine B, Cantor Rita M, Choi Oi-Wa, DeYoung Joseph, Eskin Eleazar, Fairbanks Lynn A, Fears Scott, Furterer Allison E, Huang Yu S, Ramensky Vasily, Schmitt Christopher A, Svardal Hannes, Jorgensen Matthew J, Kaplan Jay R, Villar Diego, Aken Bronwen L, Flicek Paul, Nag Rishi, Wong Emily S, Blangero John, Dyer Thomas D, Bogomolov Marina, Benjamini Yoav, Weinstock George M, Dewar Ken, Sabatti Chiara, Wilson Richard K, Jentsch J David, Warren Wesley, Coppola Giovanni, Woods Roger P, Freimer Nelson B
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Nat Genet. 2017 Dec;49(12):1714-1721. doi: 10.1038/ng.3959. Epub 2017 Oct 30.
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
通过分析来自黑长尾猴谱系样本中的多组织基因表达和全基因组遗传变异数据，我们生成了一个转录组资源，并编制了非人类灵长类动物模型中首个表达数量性状基因座（eQTL）目录。该目录每个样本包含的全基因组显著eQTL比同类人类资源更多，并识别出与性别和年龄相关的表达模式。研究结果包括一个可能在免疫功能中起作用的主调控基因座，以及一个调节海马体长链非编码RNA（lncRNA）的基因座，其表达与海马体体积相关。该资源将有助于对数量性状进行遗传学研究，包括与神经精神疾病相关的大脑和行为表型。
