LaCombe Philip, Jose Alvin, Basit Hajira, Lappin Sarah L.
SUNY Upstate Medical University
William Carey College of Osteopathic Medicine
The systolic performance of the left ventricle is determined by three factors: preload, afterload, and contractility. The Frank-Starling relationship characterizes the effect of preload, often measured by left ventricular end-diastolic volume (LVEDV) or left ventricular end-diastolic pressure (LVEDP), on systolic function. It is an intrinsic property of the heart by which an increase in left ventricular end-diastolic volume leads to increased ventricular contraction. This variability means that under normal conditions, the heart can compensate for the increased delivery of blood to the left ventricle by increasing cardiac output. The exact mechanism behind this observation is not fully elucidated, but evidence shows that increasing sarcomere length in cardiomyocytes causes an increase in the active tension generated during contraction. Heart failure results when the ventricle is no longer able to provide adequate contraction for a given LVEDV. The Frank-Starling relationship is important for understanding the physiology of heart failure and developing new approaches for treating this disease.
前负荷、后负荷和心肌收缩力。Frank-Starling关系描述了前负荷对收缩功能的影响，前负荷通常用左心室舒张末期容积（LVEDV）或左心室舒张末期压力（LVEDP）来衡量。这是心脏的一种内在特性，即左心室舒张末期容积增加会导致心室收缩增强。这种变异性意味着在正常情况下，心脏可以通过增加心输出量来补偿输送到左心室的血液增加。这一现象背后的确切机制尚未完全阐明，但有证据表明，心肌细胞中肌节长度的增加会导致收缩过程中产生的主动张力增加。当心室不再能够为给定的LVEDV提供足够的收缩力时，就会发生心力衰竭。Frank-Starling关系对于理解心力衰竭的生理学以及开发治疗这种疾病的新方法非常重要。
