Delicce Anthony V., Makaryus Amgad N.
Donald and Barbara Zucker School Medicine at Hofstra/Northwell
The Frank-Starling relationship is based on the link between the initial length of myocardial fibers and the force generated by contraction. There is a predictable relationship between the length between sarcomeres and the tension of the muscle fibers. There is an optimal length between sarcomeres at which the tension in the muscle fiber is greatest, resulting in the greatest force of contraction. If sarcomeres are closer together or further apart compared to this optimal length, there will be a decrease in contraction tension and strength. The greater the ventricular diastolic volume, the more the myocardial fibers are stretched during diastole. Within a normal physiologic range, the more the myocardial fibers are stretched, the greater the tension in the muscle fibers and the greater force of contraction of the ventricle when stimulated. The Frank-Starling relationship is the observation that ventricular output increases as preload (end-diastolic pressure) increases. See Frank–Starling Law.
弗兰克-斯塔林关系基于心肌纤维的初始长度与收缩产生的力之间的联系。肌节之间的长度与肌纤维的张力之间存在可预测的关系。肌节之间存在一个最佳长度，此时肌纤维中的张力最大，从而产生最大的收缩力。如果肌节与这个最佳长度相比靠得更近或更远，收缩张力和强度将会降低。心室舒张容积越大，心肌纤维在舒张期被拉伸得就越多。在正常生理范围内，心肌纤维被拉伸得越多，肌纤维中的张力就越大，心室在受到刺激时的收缩力也就越大。弗兰克-斯塔林关系是指观察到心室输出量随着前负荷（舒张末期压力）的增加而增加。见弗兰克-斯塔林定律。
