Mullins Tessa B., Sickinger Maryam, Zito Patrick M.
Lewis Gale Hospital - Montgomery
Advanced Institute of Dermatology
Reactive perforating collagenosis (RPC), one of the perforating dermatoses, is a rare skin disease with a characteristic transepidermal elimination of altered collagen through the epidermis. It occurs in 2 forms: an inherited form in childhood that is rare and an acquired form in adulthood, more commonly found in patients with diabetes mellitus and end-stage renal disease. Commonly, patients will have hyperkeratotic papules on the extensor areas of extremities and hands, most likely over areas of superficial trauma. The lesions are very pruritic and can grow into large, umbilicated papulonodules with a central keratotic plug that relapse and remit throughout the patient’s lifetime. Most cases are self-limited and do not require treatment.
反应性穿通性胶原病（RPC）是穿通性皮肤病之一，是一种罕见的皮肤病，其特征是改变的胶原蛋白通过表皮进行经表皮清除。它有两种形式：儿童期的遗传性形式罕见，成人期的获得性形式更常见于糖尿病和终末期肾病患者。通常，患者在四肢和手部的伸侧区域会出现角化过度丘疹，最可能出现在浅表创伤部位。这些皮损非常瘙痒，可发展为大的、脐凹状丘疹结节，中央有角质栓，在患者一生中会反复出现和缓解。大多数病例是自限性的，不需要治疗。
