Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors.

A novel series of 2-substituted-4,6-diarylpyrimidines - has been synthesized, characterized by ¹H-NMR, C-NMR and HRMS, and screened for in vitro -glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC values ranging from 19.6 ± 0.21 to 38.9 ± 0.35 μM, which is more potent than the positive control α-glucosidase inhibitor acarbose (IC = 817.38 ± 6.27 μM). Among them, was found to be the most active compound against α-glucosidase with an IC of 19.6 ± 0.21 μM. In addition, molecular docking studies were carried out to explore the binding interactions of 2-substituted-4,6-diarylpyrimidine derivatives with α-glucosidase.