Musialowska Dominika, Zbroch Edyta, Koc-Zorawska Ewa, Musialowski Piotr, Malyszko Jolanta
1 Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.
Angiology. 2018 Jul;69(6):483-489. doi: 10.1177/0003319717736158. Epub 2017 Oct 30.
Inflammation and endothelial dysfunction may play an important role in the multifactorial pathogenesis of hypertension. Endocan is also thought to play a role in cell adhesion and inflammatory disorders. The aim of the study was to compare endocan concentrations in patients with primary hypertension and healthy volunteers. There were 104 patients with hypertension (study group) and 21 healthy volunteers (control group). The correlation between endocan, catecholamines, and blood pressure control in patients with primary hypertension and the control group was analyzed. The median endocan concentration in the study group (2.03 ng/mL) was significantly higher than in the control group (1.09 ng/mL, P = .0001). Endocan concentration was correlated positively with renalase ( r = .2, P = .047) and norepinephrine ( r = .25, P = .02). Negative correlation was observed between endocan and body mass index ( r = -.25, P = .016) and leukocyte count ( r = -.36, P = .0004). The present study reports higher plasma endocan concentration in patients with treated, well-controlled primary hypertension compared with healthy volunteers. The higher endocan concentration in the study group may reflect endothelial dysfunction in this population.
炎症和内皮功能障碍可能在高血压的多因素发病机制中起重要作用。内皮糖蛋白也被认为在细胞黏附和炎症紊乱中发挥作用。本研究的目的是比较原发性高血压患者和健康志愿者体内内皮糖蛋白的浓度。研究组有104例高血压患者，对照组有21名健康志愿者。分析了原发性高血压患者和对照组中内皮糖蛋白、儿茶酚胺与血压控制之间的相关性。研究组内皮糖蛋白浓度中位数（2.03 ng/mL）显著高于对照组（1.09 ng/mL，P = .0001）。内皮糖蛋白浓度与肾酶呈正相关（r = .2，P = .047），与去甲肾上腺素呈正相关（r = .25，P = .02）。内皮糖蛋白与体重指数呈负相关（r = -.25，P = .016），与白细胞计数呈负相关（r = -.36，P = .0004）。本研究报告称，与健康志愿者相比，经过治疗且血压控制良好的原发性高血压患者血浆内皮糖蛋白浓度更高。研究组中较高的内皮糖蛋白浓度可能反映了该人群的内皮功能障碍。
