Zigmond R E
Center for Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
J Physiol (Paris). 1988;83(3):267-71.
The activity of tyrosine hydroxylase, the enzyme that catalyzes the rate-limiting step in catecholamine biosynthesis, increases in postganglionic sympathetic neurons following electrical stimulation of their afferent preganglionic input. Two types of changes in enzyme activity occur: an acute increase and a delayed and long-lasting increase. The pharmacological mechanisms involved in these transsynaptic effects and the biochemical mechanisms underlying the changes in tyrosine hydroxylase activity are discussed.
酪氨酸羟化酶是催化儿茶酚胺生物合成限速步骤的酶，在节后交感神经元受到其传入节前输入的电刺激后，该酶的活性会增加。酶活性会出现两种类型的变化：急性增加以及延迟且持久的增加。本文讨论了这些跨突触效应所涉及的药理机制以及酪氨酸羟化酶活性变化背后的生化机制。
