Centre for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105, AZ, Amsterdam, The Netherlands.
Department of Haematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Respir Res. 2017 Oct 30;18(1):181. doi: 10.1186/s12931-017-0663-1.
Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis.
结核病是一种具有毁灭性的传染病，在全球范围内导致了许多死亡。最近的研究表明，中性粒细胞胞外诱捕网（NETs）在宿主对结核病的反应中起作用。本研究旨在为人类结核病患者循环中 NETs 的释放提供证据。为此，我们测量了 64 例活动性肺结核患者和 32 例健康对照者血浆中的核小体浓度，并结合中性粒细胞弹性蛋白酶进行检测。与局部健康献血者相比，活动性肺结核患者的血浆核小体和弹性蛋白酶水平升高。此外，核小体和弹性蛋白酶水平呈正相关。这些发现为活动性肺结核患者循环中 NETs 的释放提供了首个证据。
