Wu Xiaochang
Department of General Surgery, Huzhou Central Hospital, Zhejiang University Huzhou Hospital, Zhejiang, China.
Pak J Pharm Sci. 2017 Sep;30(5(Special)):1833-1836.
To explore the effect of metformin combined with chemotherapeutic agents on gastric cancer cell line AGS, 24 patients with gastric cancer were tracked for treatment. CCK-8, Transwell model and flow cytometry were used to detect the cell proliferation, migration ability and other indexes. The metformin inhibited the AGS cell proliferation in a dose- and time-dependent manner (P<0.05). The application of metformin, cisplatin, adriamycin or paclitaxel alone could effectively lower the migration and invasion ability of AGS cells. The metformin in combination with the three chemotherapeutic agents could effectively promote the apoptosis of AGS cells. The metformin in combination with chemotherapeutic agents can effectively and apparently treat the patients with gastric cancer, more significantly in clinic compared to the traditional administration mode. It can effectively promote the apoptosis of AGS cells, thus, it's worth adopting in clinic.
为探讨二甲双胍联合化疗药物对胃癌细胞系AGS的影响，对24例胃癌患者进行跟踪治疗。采用CCK-8、Transwell模型和流式细胞术检测细胞增殖、迁移能力等指标。二甲双胍以剂量和时间依赖性方式抑制AGS细胞增殖（P<0.05）。单独应用二甲双胍、顺铂、阿霉素或紫杉醇均可有效降低AGS细胞的迁移和侵袭能力。二甲双胍联合三种化疗药物可有效促进AGS细胞凋亡。二甲双胍联合化疗药物能有效且显著地治疗胃癌患者，在临床上比传统给药方式更显著。它能有效促进AGS细胞凋亡，因此值得在临床上采用。
