Departments of Chemistry, Berkeley, California 94720-1460.
Departments of Chemistry, Berkeley, California 94720-1460; Molecular and Cell Biology, Berkeley, California 94720-1460; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720-1460; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720.
J Biol Chem. 2018 Mar 30;293(13):4628-4635. doi: 10.1074/jbc.R117.000176. Epub 2017 Oct 30.
Transition metals have been recognized and studied primarily in the context of their essential roles as structural and metabolic cofactors for biomolecules that compose living systems. More recently, an emerging paradigm of transition-metal signaling, where dynamic changes in transitional metal pools can modulate protein function, cell fate, and organism health and disease, has broadened our view of the potential contributions of these essential nutrients in biology. Using copper as a canonical example of transition-metal signaling, we highlight key experiments where direct measurement and/or visualization of dynamic copper pools, in combination with biochemical, physiological, and behavioral studies, have deciphered sources, targets, and physiological effects of copper signals.
过渡金属主要在作为构成生命系统的生物分子的结构和代谢辅因子的重要作用的背景下得到认识和研究。最近，一种新兴的过渡金属信号传递模式出现了，即过渡金属池中的动态变化可以调节蛋白质功能、细胞命运以及生物体的健康和疾病，这拓宽了我们对这些必需营养素在生物学中潜在贡献的认识。本文以铜作为过渡金属信号传递的典型例子，强调了一些关键实验，这些实验通过直接测量和/或可视化动态铜池，并结合生化、生理和行为研究，解析了铜信号的来源、靶标和生理效应。
