Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Sci Rep. 2017 Oct 30;7(1):14317. doi: 10.1038/s41598-017-14841-8.
Elizabethkingia anophelis has become an emerging infection in humans. Recent research has shown that previous reports of E. meningoseptica infections might in fact be caused by E. anophelis. We aimed to investigate the genomic features, phylogenetic relationships, and comparative genomics of this emerging pathogen. Elizabethkingia anophelis strain EM361-97 was isolated from the blood of a cancer patient in Taiwan. The total length of the draft genome was 4,084,052 bp. The whole-genome analysis identified the presence of a number of antibiotic resistance genes, which corresponded with the antibiotic susceptibility phenotype of this strain. Based on the average nucleotide identity, the phylogenetic analysis revealed that E. anophelis EM361-97 was a sister group to E. anophelis FMS-007, which was isolated from a patient with T-cell non-Hodgkin's lymphoma in China. Knowledge of the genomic characteristics and comparative genomics of E. anophelis will provide researchers and clinicians with important information to understand this emerging microorganism.
嗜水气单胞菌已成为人类的一种新出现的感染源。最近的研究表明，以前关于脑膜败血伊丽莎白菌感染的报告实际上可能是由嗜水气单胞菌引起的。我们旨在研究这种新出现的病原体的基因组特征、系统发育关系和比较基因组学。嗜水气单胞菌菌株 EM361-97 从中国台湾一位癌症患者的血液中分离出来。该草案基因组的总长度为 4,084,052 bp。全基因组分析确定了存在多种抗生素耐药基因，这与该菌株的抗生素药敏表型相对应。基于平均核苷酸同一性，系统发育分析表明，嗜水气单胞菌 EM361-97 是从中国一位 T 细胞非霍奇金淋巴瘤患者中分离出的嗜水气单胞菌 FMS-007 的姐妹群。了解嗜水气单胞菌的基因组特征和比较基因组学将为研究人员和临床医生提供重要信息，以帮助理解这种新出现的微生物。
