Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, SE-90 187, Umeå, Sweden.
Department of Biology, Plant Biology Unit, University of Fribourg, Rue Albert-Gockel 3, PER04, CH-1700, Fribourg, Switzerland.
Nat Plants. 2017 Nov;3(11):854-858. doi: 10.1038/s41477-017-0039-z. Epub 2017 Oct 30.
The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance.
植物根的最外层细胞层（表皮）不断面临环境挑战。表皮外质膜域含有 PENETRATION3（PEN3）/ABCG36/PDR8 ATP 结合盒转运蛋白，该蛋白赋予几种病原体的非宿主抗性。在这里，我们表明拟南芥内质网滞留 PEN3（EAP3）BTB/POZ 结构域蛋白特异性介导 PEN3 从内质网输出，并赋予对根穿透真菌的抗性，为 BTB/POZ 结构域蛋白依赖的膜运输在抗病性中的作用提供了重要证据。
