Huetz F, Lucotte G, Kahan A, Amor B
Rev Rhum Mal Osteoartic. 1987 Mar;54(3):175-8.
The restriction polymorphism Taq I of the 3.5 kb fragment of Class I HLA sequences is tested in patients suffering from ankylosing spondylarthritis, with or without antigen HLA B27. In a reference population, the frequency of this polymorphism is higher than that of allele B27. All B27 individuals, ill or not, present the polymorphic band, also present in some individuals B12. The distribution of this band is studied, in unrelated individuals serotyped for HLA B as well as members of families with spondylarthritis. The presence of the variable 3.5 kb band is not automatically correlated with the gene of the disease in corresponding individuals.
在患有强直性脊柱炎、有或没有HLA B27抗原的患者中，检测了I类HLA序列3.5 kb片段的Taq I限制性多态性。在一个参考人群中，这种多态性的频率高于等位基因B27的频率。所有B27个体，无论患病与否，都呈现出多态性条带，在一些B12个体中也有呈现。研究了该条带在HLA B血清分型的无关个体以及脊柱关节炎家族成员中的分布。在相应个体中，可变的3.5 kb条带的存在与疾病基因并不自动相关。
