在接受高效抗逆转录病毒治疗的尼日利亚患者中，患者相关因素与药物依从性之间的关系。
The relationship between patient-related factors and medication adherence among Nigerian patients taking highly active anti-retroviral therapy.
作者信息
Nduaguba Sabina O, Soremekun Rebecca O, Olugbake Olubusola A, Barner Jamie C
机构信息
Health Outcomes and Pharmacy Practice Division, The University of Texas at Austin College of Pharmacy, Austin, Texas, United States.
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.
出版信息
Afr Health Sci. 2017 Sep;17(3):738-745. doi: 10.4314/ahs.v17i3.16.
BACKGROUND
Through several initiatives, there are increasingly more people who have access to anti-retroviral therapy. Adherence to therapy is, however, necessary for successful management of disease.
OBJECTIVES
The objectives of this study were to describe adherence rates and determine what patient-related factors are related to adherence to anti-retroviral therapy among adult patients in an HIV clinic located in Lagos, Nigeria.
METHODS
Adherence was measured using the two-week self-recall method. Barriers, satisfaction with therapy, and socio-demographic and clinical variables served as independent variables. Data were collected via self-administered surveys.
RESULTS
Most of the patients (79.5%) reported 100% adherence. The significant (p<0.05) barriers to adherence were forgetfulness, running out of medication, alcohol use, and medication side effects. For every unit increase in the number of barriers, patients were 60.8% less likely to be 100% adherent (p <0.05, odds ratio, OR = 0.392, 95% CI = 0.295-0.523).
CONCLUSION
Interventions should target helping patients cope with forgetfulness, specifically employing strategies to overcome busyness in schedules, being away from home, and tiredness.
背景
通过多项举措，越来越多的人能够获得抗逆转录病毒疗法。然而，坚持治疗对于疾病的成功管理至关重要。
目的
本研究的目的是描述依从率，并确定在尼日利亚拉各斯一家艾滋病毒诊所的成年患者中，哪些与患者相关的因素与抗逆转录病毒治疗的依从性有关。
方法
使用两周自我回忆法测量依从性。障碍、对治疗的满意度以及社会人口统计学和临床变量作为自变量。通过自行填写的调查问卷收集数据。
结果
大多数患者（79.5%）报告依从率为100%。依从性的显著（p<0.05）障碍包括健忘、药物用完、饮酒和药物副作用。每增加一个障碍单位，患者达到100%依从性的可能性就降低60.8%（p<0.05，比值比，OR=0.392，95%置信区间=0.295-0.523）。
结论
干预措施应旨在帮助患者应对健忘问题，特别是采用策略克服日程繁忙、离家在外和疲劳等情况。
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