Zhu Sheng-Xing, Tong Xian-Zhou, Zhang Shuijun
Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Department of The Second General Surgery, People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China.
Oncol Lett. 2017 Oct;14(4):4505-4510. doi: 10.3892/ol.2017.6777. Epub 2017 Aug 21.
MicroRNAs (miRs) are involved in many aspects of cell biology, including cell proliferation and apoptosis, two critical aspects of tumor biology. We investigated the effect of miR-711 on Bcl-2 expression in human MGC803 gastric cancer cells and the mechanism of cell proliferation, apoptosis, and invasion. Expression of miR-711 and Bcl-2 was significantly increased in gastric adenocarcinoma compared to adjacent normal tissue. Inhibition of miR-711 in MGC803 gastric cancer cells decreased the expression of Bcl-2, decreased cell proliferation, decreased the invasion ability, and increased apoptosis. The expression of Bcl-2 protein correlated with clinical staging, lymph node metastasis, and tumor differentiation in patients with gastric cancer. The expression of miR-711 positively correlated with the expression of Bcl-2, suggesting that miR-711 and Bcl-2 are co-regulated and involved in the development of gastric cancer.
微小RNA（miR）参与细胞生物学的许多方面，包括细胞增殖和凋亡，这是肿瘤生物学的两个关键方面。我们研究了miR-711对人MGC803胃癌细胞中Bcl-2表达的影响以及细胞增殖、凋亡和侵袭的机制。与相邻正常组织相比，胃腺癌中miR-711和Bcl-2的表达显著增加。抑制MGC803胃癌细胞中的miR-711可降低Bcl-2的表达，减少细胞增殖，降低侵袭能力，并增加凋亡。Bcl-2蛋白的表达与胃癌患者的临床分期、淋巴结转移和肿瘤分化相关。miR-711的表达与Bcl-2的表达呈正相关，表明miR-711和Bcl-2共同调节并参与胃癌的发生发展。
