环状 RNA 在子痫前期患者胎盘组织中的表达谱分析。
The profile analysis of circular RNAs in human placenta of preeclampsia.
机构信息
*These authors contributed equally to this paper.
出版信息
Exp Biol Med (Maywood). 2018 Oct;243(14):1109-1117. doi: 10.1177/1535370218813525. Epub 2018 Nov 20.
Abstract
The abnormal expression of many regulatory factors may be involved in the development of PE. circRNAs are proved to have a series of important biological functions; however, reports about circRNA and PE are rare. In this work, we evaluated the profile analysis of circRNAs in human placenta of PE by RNA-seq and found some newly differentially expressed circRNAs which might be involved in PE. Combined with bioinformatics analysis, their possible functions were preliminarily discussed.
摘要
许多调节因子的异常表达可能与 PE 的发生有关。 circRNAs 被证明具有一系列重要的生物学功能；然而，关于 circRNA 和 PE 的报道很少。在这项工作中，我们通过 RNA-seq 评估了 PE 患者胎盘组织中 circRNAs 的表达谱分析，发现了一些新的差异表达 circRNAs，它们可能与 PE 有关。结合生物信息学分析，初步探讨了它们可能的功能。
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