*These authors contributed equally to this paper.
Exp Biol Med (Maywood). 2018 Oct;243(14):1109-1117. doi: 10.1177/1535370218813525. Epub 2018 Nov 20.
The abnormal expression of many regulatory factors may be involved in the development of PE. circRNAs are proved to have a series of important biological functions; however, reports about circRNA and PE are rare. In this work, we evaluated the profile analysis of circRNAs in human placenta of PE by RNA-seq and found some newly differentially expressed circRNAs which might be involved in PE. Combined with bioinformatics analysis, their possible functions were preliminarily discussed.
许多调节因子的异常表达可能与 PE 的发生有关。 circRNAs 被证明具有一系列重要的生物学功能；然而，关于 circRNA 和 PE 的报道很少。在这项工作中，我们通过 RNA-seq 评估了 PE 患者胎盘组织中 circRNAs 的表达谱分析，发现了一些新的差异表达 circRNAs，它们可能与 PE 有关。结合生物信息学分析，初步探讨了它们可能的功能。
