McGregor Alyson J, Beauchamp Gillian A, Wira Charles R, Perman Sarah M, Safdar Basmah
Warren Alpert Medical School of Brown University, Department of Emergency Medicine, Division of Sex and Gender in Emergency Medicine, Providence, Rhode Island.
Oregon Health & Science University, Department of Emergency Medicine, Portland, Oregon.
West J Emerg Med. 2017 Oct;18(6):1079-1090. doi: 10.5811/westjem.2017.8.34997. Epub 2017 Oct 6.
The National Institutes of Health recently highlighted the significant role of sex as a biological variable (SABV) in research design, outcome and reproducibility, mandating that this variable be accounted for in all its funded research studies. This move has resulted in a rapidly increasing body of literature on SABV with important implications for changing the clinical practice of emergency medicine (EM). Translation of this new knowledge to the bedside requires an understanding of how sex-based research will ultimately impact patient care. We use three case-based scenarios in acute myocardial infarction, acute ischemic stroke and important considerations in pharmacologic therapy administration to highlight available data on SABV in evidence-based research to provide the EM community with an important foundation for future integration of patient sex in the delivery of emergency care as gaps in research are filled.
美国国立卫生研究院最近强调了性别作为生物学变量（SABV）在研究设计、结果和可重复性方面的重要作用，要求在其所有资助的研究中都要考虑这一变量。这一举措导致了关于SABV的文献迅速增加，对改变急诊医学（EM）的临床实践具有重要意义。将这些新知识应用到临床需要了解基于性别的研究最终将如何影响患者护理。我们使用急性心肌梗死、急性缺血性中风的三个基于病例的场景以及药物治疗管理中的重要考虑因素，来突出循证研究中关于SABV的现有数据，以便在填补研究空白时，为急诊医学界在提供急诊护理时将患者性别纳入其中提供重要的基础。
