Yang Yi, Wickless Heather
Department of Dermatology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9069, USA.
Department of Dermatology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., MSC 9069, Dallas, TX 75390-9069, USA.
Leuk Res Rep. 2017 Oct 16;8:14-18. doi: 10.1016/j.lrr.2017.10.001. eCollection 2017.
To determine some of the key clinical features that help prompt clinicians to pursue additional work-up for evaluation of CNS involvement of MF, we conducted a systematic review to better define characteristics, treatments, outcomes, and mortality in these patients. Our analyses indicated that neurologic surveillance after the diagnosis of MF is crucial. Review of systems should include change in mentation, vestibular, and ocular symptoms. Progression to CNS involvement does not always occur in tandem with cutaneous disease burden. Single-agent therapies can delay disease progression and improve prognosis. Multi-agent treatment does not improve survival.
为了确定一些有助于促使临床医生对蕈样肉芽肿（MF）中枢神经系统受累进行进一步检查评估的关键临床特征，我们进行了一项系统评价，以更好地明确这些患者的特征、治疗方法、结局及死亡率。我们的分析表明，MF诊断后的神经学监测至关重要。系统回顾应包括精神状态、前庭及眼部症状的变化。中枢神经系统受累的进展并不总是与皮肤疾病负担同步发生。单药治疗可延缓疾病进展并改善预后。多药联合治疗并不能提高生存率。
