Liu Lingxi, Zhang Xiaoyan
Department of Dermatology, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
Medicine (Baltimore). 2025 May 9;104(19):e42279. doi: 10.1097/MD.0000000000042279.
Mycosis fungoides, the most prevalent subtype of cutaneous T-cell lymphoma, primarily targets areas of the skin that of not exposed to sunlight. Nevertheless, it can involve extracutaneous tissues at any disease stage, especially during its advanced phases. Research suggests that all extracutaneous organs might be susceptible, though such cases are more commonly reported in autopsy studies and less so in clinical setting. The most recent comprehensive review of such extracutaneous manifestations in mycosis fungoides occurred almost a decade ago. With the aim of enhancing clinicians' understanding of these extracutaneous manifestations to improve diagnostic accuracy and patient outcomes, this updated review provides a current synthesis of the rare instances of extracutaneous involvement in mycosis fungoides.
蕈样肉芽肿是皮肤T细胞淋巴瘤最常见的亚型，主要侵犯未暴露于阳光的皮肤区域。然而，在疾病的任何阶段它都可能累及皮肤外组织，尤其是在晚期。研究表明，所有皮肤外器官都可能易感，不过此类病例在尸检研究中报道得更为常见，在临床环境中则较少。关于蕈样肉芽肿皮肤外表现的最新全面综述大约是在十年前进行的。为了增强临床医生对这些皮肤外表现的理解，以提高诊断准确性和患者预后，本更新综述对蕈样肉芽肿皮肤外受累的罕见病例进行了当前的综合阐述。
