铜催化有氧氧化[2 + 3]环化/芳构化级联反应：原子经济性合成四取代 4,5-双羰基咪唑。
Copper-Catalyzed Aerobic Oxidative [2 + 3] Cyclization/Aromatization Cascade Reaction: Atom-Economical Access to Tetrasubstituted 4,5-Biscarbonyl Imidazoles.
机构信息
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, People's Republic of China.
出版信息
Org Lett. 2017 Nov 17;19(22):6056-6059. doi: 10.1021/acs.orglett.7b02767. Epub 2017 Oct 31.
An atom-economical method for accessing tetrasubstituted 4,5-biscarbonylimidazoles by reaction between glycine derivatives and 5-alkoxyoxazoles is reported. The method, which involves a copper-catalyzed aerobic oxidative [2 + 3] cyclization/aromatization cascade process, starts from readily available and inexpensive materials, uses molecular oxygen as a co-oxidant, and has a broad substrate scope.
本文报道了一种原子经济性方法，通过甘氨酸衍生物和 5-烷氧基恶唑之间的反应来合成四取代的 4,5-双羰基咪唑。该方法涉及铜催化的有氧氧化[2+3]环化/芳构化级联反应，起始原料易得且廉价，使用分子氧作为共氧化剂，具有广泛的底物范围。
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