State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Chem Commun (Camb). 2013 Feb 18;49(14):1410-2. doi: 10.1039/c2cc37805a.
A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd-Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as the oxidant, but also as an oxygen source in the approach. The process allows quick and atom-economical assembly of 3-acylindoles from readily available starting materials and tolerates a broad range of functional groups.
证明了一种在 Pd-Cu 共催化氧化条件下合成 3-酰基吲哚的新型高效催化方法。叔丁基过氧化氢 (TBHP) 不仅作为氧化剂，而且在该方法中还作为氧源。该过程允许从易得的起始原料快速且原子经济性地组装 3-酰基吲哚，并容忍广泛的官能团。
