Sarode Karan, Hussain Saad S, Tyroch Alan, Mukherjee Debabrata
Paul L. Foster School of Medicine, El Paso, Texas, TX, United States.
Division of Cardiology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX, United States.
Cardiovasc Hematol Disord Drug Targets. 2017;17(3):167-179. doi: 10.2174/1871529X17666171030120851.
Viscoelastic tests (VETs) such as thromboelastography, rotational thromboelastography, and the Sonoclot Analyzer assess the entire process of clot formation through dissolution in real-time, and may provide additional therapeutic value to conventional laboratory coagulation tests. With the ability to obtain rapid results and identify specific coagulopathies, VETs has been examined in a variety of clinical scenarios, including cardiac surgery, trauma, obstetric emergencies, and liver transplant.
This review provides a summary of clinical trials utilizing VETs in the aforementioned clinical scenarios, and suggests that VETs have demonstrated a capability to identify coagulopathies, utility in guiding algorithms to reduce the amount of transfusions, and a limited ability to predict bleeding events or mortality.
黏弹性测试（VETs），如血栓弹力图、旋转血栓弹力图和Sonoclot分析仪，可实时评估凝血块形成至溶解的全过程，可能为传统实验室凝血测试提供额外的治疗价值。凭借能够快速得出结果并识别特定凝血病的能力，VETs已在多种临床场景中得到检验，包括心脏手术、创伤、产科急症和肝移植。
本综述总结了在上述临床场景中使用VETs的临床试验，并表明VETs已证明有能力识别凝血病，在指导算法以减少输血量方面有实用价值，以及预测出血事件或死亡率的能力有限。
