通过铜催化的氧化C(sp)-H/C(sp)-H交叉偶联反应新颖且简便地合成1-苯并氮杂卓类化合物。
Novel and facile synthesis of 1-benzazepines via copper-catalyzed oxidative C(sp)-H/C(sp)-H cross-coupling.
作者信息
Wang Rui, Jin Ruo-Xing, Qin Zi-Yang, Bian Kang-Jie, Wang Xi-Sheng
机构信息
Department of Chemistry, University of Science and Technology of China, 96 JinZhai Road, Hefei, Anhui 230026, China.
出版信息
Chem Commun (Camb). 2017 Nov 9;53(90):12229-12232. doi: 10.1039/c7cc07027f.
PMID:29086775
Abstract
A novel and facile synthetic strategy for the construction of 1-benzazepines has been developed via copper-catalyzed oxidative C(sp)-H/C(sp)-H cross-coupling directly from two inert C-H bonds. This transformation represents an atom- and step-economical way to synthesize biologically important seven-membered benzo-heterocycles compared with the known methods.
摘要
通过铜催化的氧化C(sp)-H/C(sp)-H交叉偶联，直接从两个惰性C-H键出发，开发了一种新颖且简便的合成1-苯并氮杂卓的策略。与已知方法相比，这种转化代表了一种合成具有生物学重要性的七元苯并杂环的原子经济性和步骤经济性的方法。
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