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基于丙氨酸的双硫脲异构体金属结合行为的比较研究。

A comparative study of the metal binding behavior of alanine based bis-thiourea isomers.

作者信息

Fakhar Imran, Yamin Bohari M, Hasbullah Siti Aishah

机构信息

School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.

出版信息

Chem Cent J. 2017 Aug 4;11(1):76. doi: 10.1186/s13065-017-0304-2.

DOI:10.1186/s13065-017-0304-2
PMID:29086858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5544659/
Abstract

Two new symmetrical bis-thiourea, 2,2'-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3'-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropanoic acid] (1B) were synthesized by the reaction of terephthaloyl chloride with α- and β-alanine in good yields. Their binding properties were investigated with various metal cations using UV-Vis titration experiments. Both isomers exhibited effective binding with Ag, Cu, Hg, Pb, Fe and Fe cations. However, in the presence of other cations, such as Na, Ni, Co, Cd, Zn, Mn, Mg, Ca, Sn, Al, and anions tetrabutylammonium Cl and HPO, no interaction occurred. Both isomers displayed similar trends towards binding with metal cations.

摘要

通过对苯二甲酰氯与α-丙氨酸和β-丙氨酸反应，以良好的产率合成了两种新的对称双硫脲，即2,2'-[{(对苯二甲酰基双(氮杂二亚基)双(碳硫酰基)双(氮杂二亚基)}二丙酸]（1A）和3,3'-[{(对苯二甲酰基双(氮杂二亚基)双(碳硫酰基)双(氮杂二亚基)}二丙酸]（1B）。使用紫外可见滴定实验研究了它们与各种金属阳离子的结合特性。两种异构体均与Ag、Cu、Hg、Pb、Fe和Fe阳离子表现出有效的结合。然而，在存在其他阳离子（如Na、Ni、Co、Cd、Zn、Mn、Mg、Ca、Sn、Al）以及阴离子四丁基氯化铵和磷酸氢根的情况下，未发生相互作用。两种异构体在与金属阳离子结合方面表现出相似的趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/705581e738d8/13065_2017_304_Fig17_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/86eb5b700285/13065_2017_304_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/705581e738d8/13065_2017_304_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/ca176be006fc/13065_2017_304_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/43fd93803ebe/13065_2017_304_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/37a2979b2fb8/13065_2017_304_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/78b4f533e976/13065_2017_304_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/80da4b3b1018/13065_2017_304_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/25a550843330/13065_2017_304_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/7352041d4019/13065_2017_304_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/e98c15d5458a/13065_2017_304_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/3c5f7db418b6/13065_2017_304_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/78921bd94447/13065_2017_304_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/206c879e0b7f/13065_2017_304_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/665143042e18/13065_2017_304_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/a46d271dbde7/13065_2017_304_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/dc805c683c12/13065_2017_304_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/37888ebe626e/13065_2017_304_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/b0eec9a7a9f5/13065_2017_304_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/86eb5b700285/13065_2017_304_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9832/5544659/705581e738d8/13065_2017_304_Fig17_HTML.jpg

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