Prasad C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Schizophr Res. 1988 Nov-Dec;1(6):411-5. doi: 10.1016/0920-9964(88)90023-0.
When rats are given dopaminergic antagonists (neuroleptics) continuously for several days behavioral supersensitivity to dopaminergic agonists results. This supersensitivity, however, declines rapidly on neuroleptic withdrawal. The data presented here, however, are the first to show that the supersensitivity persists for a longer duration (greater than 100 days) if the neuroleptic is administered continuously for 1 year. Oral administration of 0.76 +/- 0.13 mg/kg/day cyclo(His-Pro), a peptide exhibiting dopaminergic agonist-like properties, during neuroleptic withdrawal did not change the course of dopaminergic supersensitivity reversal.
当大鼠连续数天给予多巴胺能拮抗剂（抗精神病药）时，会对多巴胺能激动剂产生行为超敏反应。然而，这种超敏反应在停用抗精神病药后会迅速下降。不过，此处呈现的数据首次表明，如果连续给予抗精神病药1年，超敏反应会持续更长时间（超过100天）。在停用抗精神病药期间，口服0.76±0.13毫克/千克/天的环（组氨酸-脯氨酸），一种具有多巴胺能激动剂样特性的肽，并不会改变多巴胺能超敏反应逆转的进程。
