Reduction of dopaminergic supersensitivity by a single dose of amphetamine.

Chronic administration of haloperidol in rats resulted in a supersensitivity to apomorphine-induced stereotypy. This behavioral supersensitivity was reduced by a single administration of d-amphetamine given 2 days after the termination of haloperidol injections. The reduction of haloperidol-induced supersensitivity by amphetamine lasted for at least 3 days after amphetamine injection.