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单次服用苯丙胺可降低多巴胺能超敏反应。

Reduction of dopaminergic supersensitivity by a single dose of amphetamine.

作者信息

Haracz J L, Tseng L F

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(2):131-3. doi: 10.1007/BF00498568.

DOI:10.1007/BF00498568
PMID:6106902
Abstract

Chronic administration of haloperidol in rats resulted in a supersensitivity to apomorphine-induced stereotypy. This behavioral supersensitivity was reduced by a single administration of d-amphetamine given 2 days after the termination of haloperidol injections. The reduction of haloperidol-induced supersensitivity by amphetamine lasted for at least 3 days after amphetamine injection.

摘要

对大鼠长期施用氟哌啶醇会导致对阿扑吗啡诱导的刻板行为产生超敏反应。在氟哌啶醇注射结束后2天给予一次右旋苯丙胺，可降低这种行为超敏反应。在注射苯丙胺后，苯丙胺对氟哌啶醇诱导的超敏反应的降低作用至少持续3天。

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Reduction of dopaminergic supersensitivity by a single dose of amphetamine.单次服用苯丙胺可降低多巴胺能超敏反应。
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引用本文的文献

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Response changes after repeated low apomorphine: dopamine autoreceptor desensitization or learning?重复给予低剂量阿扑吗啡后的反应变化：多巴胺自身受体脱敏还是学习效应？
Psychopharmacology (Berl). 1984;83(2):188-93. doi: 10.1007/BF00429733.
2
Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments.多巴胺激动剂预处理可逆转快速眼动睡眠剥夺大鼠中阿扑吗啡诱导的刻板行为和攻击行为的增加。
Psychopharmacology (Berl). 1988;94(1):79-83. doi: 10.1007/BF00735885.

本文引用的文献

1
Studies on heptazone (6-morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs.与其他镇痛药相比，庚嗪酮（6-吗啉基-4,4-二苯基-3-庚酮盐酸盐）的研究。
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Stereotypic and anticataleptic activities of amphetamine after intracerebral injections.
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Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol.慢性服用氟哌啶醇后多巴胺能超敏反应的行为学证据。
Life Sci. 1974 Mar 1;14(5):887-98. doi: 10.1016/0024-3205(74)90078-2.
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Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine.长期服用氟哌啶醇、氯氮平和硫利达嗪后超敏反应的行为学证据。
Life Sci. 1976 Sep 1;19(5):725-31. doi: 10.1016/0024-3205(76)90170-3.
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Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa.通过给予左旋多巴逆转多巴胺受体超敏反应的两种表现。
Res Commun Chem Pathol Pharmacol. 1977 Mar;16(3):411-23.
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L-DOPA reversal of hyperdopaminergic behaviour.左旋多巴对多巴胺能亢进行为的逆转作用。
Life Sci. 1978 Mar;22(12):1027-32. doi: 10.1016/0024-3205(78)90271-0.
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Dopamine agonists reverse the elevated 3H-neuroleptic binding in neuroleptic-pretreated rats.
Life Sci. 1979 Apr 16;24(16):1447-52. doi: 10.1016/0024-3205(79)90027-4.
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Subsensitivity of the rat striatal dopaminergic system after treatment with bromocriptine: effects on [3H]spiperone binding and dopamine-stimulated cyclic AMP formation.用溴隐亭治疗后大鼠纹状体多巴胺能系统的敏感性降低：对[3H]螺哌隆结合及多巴胺刺激的环磷酸腺苷形成的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Sep;304(2):141-5. doi: 10.1007/BF00495550.
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Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia.多巴胺能超敏反应：多巴胺激动剂、胆碱能药物、抗胆碱能药物及用于治疗迟发性运动障碍的药物的影响
Psychopharmacology (Berl). 1979 Apr 11;62(2):111-6. doi: 10.1007/BF00427122.
10
Dopaminergic supersensitivity after neuroleptics: time-course and specificity.抗精神病药物后的多巴胺能超敏反应：时间进程与特异性
Psychopharmacology (Berl). 1978 Dec 15;60(1):1-11. doi: 10.1007/BF00429171.