Ghiringhelli S, Cozzi E, Tsialtas D
Division of Cardiology, Ospedale Civile di Breno, Italy.
Cardiovasc Drugs Ther. 1988 Jul;2(2):211-8. doi: 10.1007/BF00051236.
The antihypertensive effects of once-daily administration of celiprolol 400 mg were compared with those of once-daily enalapril 20 mg in 20 mild to moderate essential hypertensives in a single-blind study in which the subjects were randomized to 2 weeks' treatment with either drug, preceded by 2 weeks of placebo administration. Supine and standing systolic blood pressure (SBP), diastolic pressure (DBP), and heart rate (HR) were measured at rest and during exercise (exercise bicycle with increasing work loads up to 100 watts) at the end of either period, 20 to 24 hr after drug or placebo administration. Compared to placebo, both celiprolol and enalapril reduced resting supine and standing SBP and DBP to a marked and similar extent; resting HR was unaffected by enalapril, while celiprolol produced modest reductions. During exercise, however, celiprolol significantly attenuated rises in SBP and HR, while enalapril did not. Indexes of cardiac function at rest obtained by echocardiography and systolic time intervals were unaffected by either drug. Thus, despite similar reductions by both drugs in resting blood pressures, celiprolol produced better antihypertensive effects during exercise than enalapril.
在一项单盲研究中，将20例轻度至中度原发性高血压患者随机分为两组，分别接受为期2周的塞利洛尔400mg每日一次给药或依那普利20mg每日一次给药治疗，治疗前先进行2周的安慰剂给药。在每个治疗期末，即给药或安慰剂后20至24小时，测量静息和运动时（使用功率逐渐增加至100瓦的运动自行车）的仰卧位和站立位收缩压（SBP）、舒张压（DBP）和心率（HR）。与安慰剂相比，塞利洛尔和依那普利均能显著且相似程度地降低静息仰卧位和站立位SBP及DBP；依那普利对静息HR无影响，而塞利洛尔可使其轻度降低。然而，在运动期间，塞利洛尔能显著减轻SBP和HR的升高，而依那普利则不能。超声心动图和收缩期时间间期测得的静息心功能指标不受两种药物的影响。因此，尽管两种药物对静息血压的降低作用相似，但塞利洛尔在运动期间的降压效果优于依那普利。
