Pickering T G, Case D B, Sullivan P A, Laragh J H
Am J Cardiol. 1982 Apr 21;49(6):1566-8. doi: 10.1016/0002-9149(82)90392-7.
Captopril and propranolol were given alone and in combination to 13 hypertensive men and the effects studied at rest (seated, supine and standing) and during exercise. The two drugs were equipotent at rest, and individual patients showed similar blood pressure responses to the two drugs. Both produced slight reduction of urinary aldosterone; when given in combination, both blood pressure and aldosterone were further reduced. During exercise the increase in blood pressure was unaffected by captopril but reduced by propranolol, and there was no correlation between individual responses to the two drugs. It is concluded that the similar effects of the two drugs on resting blood pressure are consistent with their effects on the renin-angiotensin system.
对13名高血压男性单独及联合给予卡托普利和普萘洛尔，并研究了静息状态（坐位、仰卧位和站立位）及运动期间的效果。两种药物在静息时等效，个体患者对两种药物表现出相似的血压反应。两者均使尿醛固酮略有降低；联合使用时，血压和醛固酮均进一步降低。运动期间，卡托普利不影响血压升高，但普萘洛尔可降低血压升高，且个体对两种药物的反应之间无相关性。结论是，两种药物对静息血压的相似作用与其对肾素-血管紧张素系统的作用一致。
