用于肠道再生的可植入合成类器官基质。
Implantable synthetic organoid matrices for intestinal regeneration.
机构信息
Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Department of Developmental Biology and the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
Nat Cell Biol. 2017 Oct 31;19(11):1307-1308. doi: 10.1038/ncb3635.
Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.
类器官是研究生理和疾病过程的有力工具。我们开发了一种完全由可互换的模块化部件组装而成的合成基质，它不仅支持多能胚胎干细胞衍生的人类肠类器官的增殖，而且增强了随后将其植入受损的小鼠结肠中的能力。
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