Liu Shuai, Zu Weisai, Zhang Jinli, Xu Liang
School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi, 832003, China.
Org Biomol Chem. 2017 Nov 15;15(44):9288-9292. doi: 10.1039/c7ob02491f.
Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan-Evans-Lam cross-coupling with aryl boronic acids for the first time. Simple copper catalysts enable the selective arylation of amino groups in ortho/meta/para-aminobenzamides under open-flask conditions. The reactions were scalable and compatible with a wide range of functional groups.
首次通过铜催化的Chan-Evans-Lam交叉偶联反应，实现了未保护氨基苯甲酰胺的化学选择性N-芳基化反应。简单的铜催化剂能够在敞口烧瓶条件下，实现邻/间/对氨基苯甲酰胺中氨基的选择性芳基化反应。该反应具有可扩展性，并且与多种官能团兼容。
