Rachmilewitz D
Department of Gastroenterology, Hadassah University Hospital, Hadassah Medical School, Jerusalem, Israel.
Aliment Pharmacol Ther. 1988;2 Suppl 1:65-73. doi: 10.1111/j.1365-2036.1988.tb00766.x.
Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastric and duodenal damage in animals and humans. The possible protection afforded by cimetidine against acute and short-term NSAID-induced mucosal damage was evaluated in five studies. Cimetidine 200 mg once daily and 400 mg once daily was found to protect the gastric mucosa against damage induced by a single dose of aspirin 1300 mg; this protection was found to be independent of gastric acid secretion. Cimetidine 200 mg q.d.s. was found to protect the stomach and duodenum against damage induced by 14 days' treatment with aspirin 650 mg q.d.s. Duodenal and gastric damage induced during a 7-day treatment period with naproxen 500 mg b.d. was prevented by cimetidine 400 mg b.d.; this dose of cimetidine also provided significant duodenal protection against damage induced by 1 week of therapy with indomethacin 50 mg t.d.s. There is no correlation between upper gastrointestinal symptoms, or between mucosal prostanoids, and the presence or absence of mucosal damage. Cimetidine is therefore effective in the prevention of mucosal damage induced by short-term treatment with NSAIDs.
非甾体抗炎药（NSAIDs）可在动物和人类中引起胃和十二指肠损伤。五项研究评估了西咪替丁对急性和短期NSAIDs诱导的黏膜损伤可能具有的保护作用。发现每日一次服用200毫克西咪替丁和每日一次服用400毫克西咪替丁可保护胃黏膜免受单次服用1300毫克阿司匹林所致的损伤；发现这种保护作用与胃酸分泌无关。发现每日四次每次200毫克西咪替丁可保护胃和十二指肠免受每日四次每次650毫克阿司匹林治疗14天所致的损伤。每日两次每次500毫克萘普生治疗7天期间所诱导的十二指肠和胃损伤可被每日两次每次400毫克西咪替丁预防；该剂量的西咪替丁还对每日三次每次50毫克吲哚美辛治疗1周所致的损伤提供了显著的十二指肠保护作用。上消化道症状之间、或黏膜前列腺素之间，与黏膜损伤的存在与否均无相关性。因此，西咪替丁在预防NSAIDs短期治疗所致的黏膜损伤方面有效。
