生长抑素抑制小细胞肺癌细胞中蛙皮素样肽的分泌。

Somatostatin inhibits the secretion of bombesin-like peptides from small cell lung cancer cells.

作者信息

Kee K A, Finan T M, Korman L Y, Moody T W

机构信息

Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, DC 20037.

出版信息

Peptides. 1988;9 Suppl 1:257-61. doi: 10.1016/0196-9781(88)90251-3.

DOI:10.1016/0196-9781(88)90251-3

PMID:2908812

Abstract

The effects of somatostatin (SRIF) on small cell lung cancer (SCLC) cell line NCI-H345 was investigated. SRIF had no effects on the basal cAMP levels or the secretion rate of bombesin-like peptides. VIP (1 microM) increased the cAMP levels approximately 10-fold and the secretion rate of bombesin-like peptides 3-fold. SRIF and its analogues inhibited the increase in the cAMP levels and the secretion rate of bombesin-like peptides caused by VIP. The order of peptide potency was (D-Trp8)SRIF > SRIF-28 = (Tyr11)SRIF > SRIF. These data suggest that functional SRIF receptors may be present on SCLC cells.

摘要

研究了生长抑素（SRIF）对小细胞肺癌（SCLC）细胞系NCI-H345的影响。SRIF对基础环磷酸腺苷（cAMP）水平或蛙皮素样肽的分泌率无影响。血管活性肠肽（VIP，1微摩尔）使cAMP水平增加约10倍，蛙皮素样肽的分泌率增加3倍。SRIF及其类似物抑制了由VIP引起的cAMP水平升高和蛙皮素样肽的分泌率增加。肽的效力顺序为（D-色氨酸8）SRIF > SRIF-28 =（酪氨酸11）SRIF > SRIF。这些数据表明SCLC细胞上可能存在功能性SRIF受体。