Zhao Yanhua, Leng Shusheng, Li Dongdong, Feng Shu, Wang Zhonghao, Tao Chuanmin
Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China.
Oncotarget. 2017 Sep 12;8(43):75326-75335. doi: 10.18632/oncotarget.20850. eCollection 2017 Sep 26.
Tumor hypoxia can influence the progression and metastasis of various cancers, including hepatocellular carcinoma (HCC). Clinical studies have indicated that hyperbaric oxygen may improve the prognosis and reduce complications in HCC patients; however, whether pulmonary function can influence the prognosis of HCC remains unknown. In this study, we found that pulmonary function was associated with clinicopathological features, including smoking, liver cirrhosis, tumor size Edmondson-Steiner grade, total operative blood loss and perioperative blood transfusion. Through Cox proportional hazard regression analysis, smoking, tumor number, tumor size, liver cirrhosis, total operative blood loss and pulmonary function were independent risk factors for overall survival (OS) and disease-free survival (DFS). In addition, poor pulmonary function was independently associated with shorter survival and increased HCC recurrence in patients. Notably, we also found that HCC with liver cirrhosis predicted worse prognosis. In summary, our study found pulmonary function could influence HCC progression. Improve pulmonary function may enhance the OS and DFS of patients with HCC.
肿瘤缺氧可影响包括肝细胞癌（HCC）在内的多种癌症的进展和转移。临床研究表明，高压氧可能改善HCC患者的预后并减少并发症；然而，肺功能是否会影响HCC的预后仍不清楚。在本研究中，我们发现肺功能与包括吸烟、肝硬化、肿瘤大小、Edmondson-Steiner分级、手术总失血量和围手术期输血等临床病理特征相关。通过Cox比例风险回归分析，吸烟、肿瘤数量、肿瘤大小、肝硬化、手术总失血量和肺功能是总生存期（OS）和无病生存期（DFS）的独立危险因素。此外，肺功能差与患者生存期缩短和HCC复发增加独立相关。值得注意的是，我们还发现伴有肝硬化的HCC预后更差。总之，我们的研究发现肺功能可影响HCC进展。改善肺功能可能提高HCC患者的OS和DFS。
