Zhang Cheng-Liang, Huang Ting, Wu Bi-Li, He Wen-Xi, Liu Dong
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Oncotarget. 2017 Sep 8;8(43):75756-75766. doi: 10.18632/oncotarget.20798. eCollection 2017 Sep 26.
Metastatic cancer cells generally cannot be eradicated using traditional surgical or chemoradiotherapeutic strategies, and disease recurrence is extremely common following treatment. On the other hand, therapies employing stem cells are showing increasing promise in the treatment of cancer. Stem cells can function as novel delivery platforms by homing to and targeting both primary and metastatic tumor foci. Stem cells engineered to stably express various cytotoxic agents decrease tumor volumes and extend survival in preclinical animal models. They have also been employed as virus and nanoparticle carriers to enhance primary therapeutic efficacies and relieve treatment side effects. Additionally, stem cells can be applied in regenerative medicine, immunotherapy, cancer stem cell-targeted therapy, and anticancer drug screening applications. However, while using stem cells to treat human cancers appears technically feasible, challenges such as treatment durability and tumorigenesis necessitate further study to improve therapeutic performance and applicability. This review focuses on recent progress toward stem cell-based cancer treatments, and summarizes treatment advantages, opportunities, and shortcomings, potentially helping to refine future trials and facilitate the translation from experimental to clinical studies.
转移性癌细胞通常无法通过传统的手术或放化疗策略根除，并且治疗后疾病复发极为常见。另一方面，采用干细胞的疗法在癌症治疗中显示出越来越大的前景。干细胞可通过归巢并靶向原发性和转移性肿瘤病灶，发挥新型递送平台的作用。经工程改造以稳定表达各种细胞毒性剂的干细胞可减小肿瘤体积并延长临床前动物模型的生存期。它们还被用作病毒和纳米颗粒载体，以提高主要治疗效果并减轻治疗副作用。此外，干细胞可应用于再生医学、免疫疗法、癌症干细胞靶向治疗和抗癌药物筛选应用。然而，虽然使用干细胞治疗人类癌症在技术上似乎可行，但诸如治疗持久性和肿瘤发生等挑战需要进一步研究，以提高治疗性能和适用性。本综述重点关注基于干细胞的癌症治疗的最新进展，并总结治疗优势、机遇和不足，可能有助于完善未来试验并促进从实验研究向临床研究的转化。
