Zhao Dan, Shi Lei-Ling, Guo Xiong-Fei, Ma Guo-Xu, Han Jian-Wei, Yang Jun-Shan, Xu Jian-Guo, Zhang Jing
a College of Chinese Medicinal Material , Jilin Agricultural University , Changchun 130118 , China.
b Department of Natural Medicinal Chemistry , Xinjiang Institute of Chinese and Ethnic Medicine , Urumqi 830002 , China.
J Asian Nat Prod Res. 2018 Dec;20(12):1116-1122. doi: 10.1080/10286020.2017.1373644. Epub 2017 Oct 31.
Two new daphnane diterpenes named tianchaterpenes A and B were isolated from the roots of Stelleropsis tianschanica. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Compounds 1 and 2 were evaluated for their cytotoxic activities against HeLa and HCT-8 cell lines. The results showed that all compounds displayed weak cytotoxicities to the HeLa cells and were inactive to the HCT-8 cells.
从天山海罂粟（Stelleropsis tianschanica）的根部分离得到了两种新的瑞香烷二萜类化合物，命名为天山萜类化合物A和B。通过化学和光谱分析，包括一维、二维核磁共振分析以及高分辨电喷雾电离质谱，阐明了它们的结构。对化合物1和2针对HeLa和HCT - 8细胞系进行了细胞毒性活性评估。结果表明，所有化合物对HeLa细胞均表现出较弱的细胞毒性，而对HCT - 8细胞无活性。
