College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China.
Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China.
Molecules. 2022 Sep 4;27(17):5701. doi: 10.3390/molecules27175701.
Four new daphnane-type diterpenes named tianchaterpenes C-F (-) and six known ones were isolated from . Their structures were elucidated based on chemical and spectral analyses. The comparisons of calculated and experimental electronic circular dichroism (ECD) methods were used to determine the absolute configurations of new compounds. Additionally, compounds - were evaluated for their cytotoxic activities against HGC-27 cell lines; the results demonstrate that compound had strong cytotoxic activities with IC values of 8.8 µM, for which activity was better than that of cisplatin (13.2 ± 0.67 µM).
从. 中分离得到了 4 个新的瑞香烷型二萜命名为田蟾蜍萜 C-F(-)和 6 个已知的。基于化学和光谱分析阐明了它们的结构。计算和实验电子圆二色谱（ECD）方法的比较用于确定新化合物的绝对构型。此外，还评估了化合物 - 对 HGC-27 细胞系的细胞毒性活性；结果表明，化合物 具有很强的细胞毒性活性，IC 值为 8.8 µM，其活性优于顺铂（13.2 ± 0.67 µM）。
