Gordon S L
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892.
J Orthop Res. 1989;7(1):138-41. doi: 10.1002/jor.1100070119.
Many factors determine the scientific merit of an NIH research grant application. This paper is intended to help optimize the organization and logical development of investigators' research ideas so that grant applications will be evaluated by the reviewers in as favorable a light as possible. The ingredients of a successful grant application are good ideas, good science, and a good application. The research should be based on a significant hypothesis and, if possible, oriented towards uncovering an important biological mechanism. Specific methods should be directly related to each aim of the project. Likewise, the specific aims should be related to each hypothesis. All aspects of the application should be clear and focused. It is best to define all assumptions, limitations, and alternative approaches. In general, the best philosophy is for the applicant to address all possible problems before the reviewers.
许多因素决定了美国国立卫生研究院（NIH）研究资助申请的科学价值。本文旨在帮助优化研究者研究思路的组织和逻辑展开，以便评审者能以尽可能有利的眼光评估资助申请。一份成功的资助申请包含好的想法、优秀的科学内容以及出色的申请。研究应基于一个重要的假设，并且如果可能的话，旨在揭示一种重要的生物学机制。具体方法应与项目的每个目标直接相关。同样，具体目标应与每个假设相关。申请的各个方面都应清晰且重点突出。最好明确所有假设、局限性以及替代方法。一般来说，最佳策略是申请人在评审者之前解决所有可能的问题。
