Drummond Peter D, Dawson Linda F, Wood Fiona M, Fear Mark W
Centre for Research on Chronic Pain and Inflammatory Diseases, Murdoch University, Perth, Western Australia, Australia.
Centre for Research on Chronic Pain and Inflammatory Diseases, Murdoch University, Perth, Western Australia, Australia.
Burns. 2018 May;44(3):582-588. doi: 10.1016/j.burns.2017.09.010. Epub 2017 Oct 28.
Stimulation of α-adrenoceptors evokes inflammatory cytokine production, boosts neurogenic inflammation and pain, and influences cellular migration and proliferation. Hence, these receptors may play a role both in normal and abnormal wound healing. To investigate this, the distribution of α-adrenoceptors in skin biopsies of burn scars (N=17), keloid scars (N=12) and unscarred skin (N=17) was assessed using immunohistochemistry. Staining intensity was greater on vascular smooth muscle in burn scars than in unscarred tissue, consistent with heightened expression of α-adrenoceptors. In addition, expression of α-adrenoceptors was greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin. These findings suggest that increased vascular expression of α-adrenoceptors could alter circulatory dynamics both in burn and keloid scars. In addition, the augmented expression of α-adrenoceptors in keloid tissue may contribute to processes that produce or maintain keloid scars, and might be a source of the uncomfortable sensations often associated with these scars.
刺激α-肾上腺素能受体会引发炎性细胞因子的产生，增强神经源性炎症和疼痛，并影响细胞迁移和增殖。因此，这些受体可能在正常和异常伤口愈合中均发挥作用。为了对此进行研究，采用免疫组织化学方法评估了α-肾上腺素能受体在烧伤瘢痕（N = 17）、瘢痕疙瘩（N = 12）和未受伤皮肤（N = 17）的皮肤活检组织中的分布情况。烧伤瘢痕血管平滑肌的染色强度高于未受伤组织，这与α-肾上腺素能受体表达增加一致。此外，瘢痕疙瘩中真皮神经纤维、血管和成纤维细胞上α-肾上腺素能受体的表达高于烧伤瘢痕或未受伤皮肤。这些发现表明，烧伤瘢痕和瘢痕疙瘩中α-肾上腺素能受体血管表达增加可能会改变循环动力学。此外，瘢痕疙瘩组织中α-肾上腺素能受体表达增加可能有助于产生或维持瘢痕疙瘩的过程，并且可能是这些瘢痕常伴有的不适感的来源。
