Hu Jia Sheng, Vogt Daniel, Sandberg Magnus, Rubenstein John L
Department of Psychiatry, University of California, San Francisco, CA 94158, USA.
Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, CA 94158, USA.
Development. 2017 Nov 1;144(21):3867-3878. doi: 10.1242/dev.132852.
Cortical interneurons are a diverse group of neurons that project locally and are crucial for regulating information processing and flow throughout the cortex. Recent studies in mice have advanced our understanding of how these neurons are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other crucial regulatory genes play in these events. We focus on cortical interneurons that are derived from the medial ganglionic eminence, as most studies have examined this interneuron population. We also assess how these data inform our understanding of neuropsychiatric disease and discuss the potential role of cortical interneurons in cell-based therapies.
皮层中间神经元是一类多样的神经元，它们在局部投射，对于调节整个皮层的信息处理和信息流至关重要。最近对小鼠的研究推进了我们对这些神经元如何被指定、迁移和成熟的理解。在这里，我们评估了一些新发现，这些发现为皮层中间神经元的发育提供了见解，揭示了它们的命运何时被决定、区域域对其发育的影响，以及关键转录因子和其他关键调控基因在这些事件中所起的作用。我们专注于源自内侧神经节隆起的皮层中间神经元，因为大多数研究都考察了这一中间神经元群体。我们还评估了这些数据如何增进我们对神经精神疾病的理解，并讨论了皮层中间神经元在基于细胞的治疗中的潜在作用。
