尿路上皮肠吻合部位癌症的预防。

Prevention of cancer at the urothelial enteric anastomotic site.

作者信息

Shands C, McDougal W S, Wright E P

机构信息

Department of Urology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

出版信息

J Urol. 1989 Jan;141(1):178-81. doi: 10.1016/s0022-5347(17)40636-7.

DOI:10.1016/s0022-5347(17)40636-7

PMID:2908946

Abstract

An animal model of ureterosigmoidostomy was employed to elucidate the etiology of urinary intestinal anastomotic cancer. One hundred ninety-four rats were divided into five groups: vesicosigmoidostomy rats fed water without drug (controls); those fed ammonium chloride, or sodium bicarbonate, or ascorbic acid; and, finally, vesicosigmoid interposition rats. A significantly decreased incidence of cancer was evident only in the bowel interposition group (p less than 0.001). Ascorbic acid and altered urinary pH were not prophylactic. Possible mechanisms are discussed.

摘要

采用输尿管乙状结肠吻合术动物模型来阐明尿路肠吻合口癌的病因。194只大鼠被分为五组：膀胱乙状结肠吻合术大鼠饮用不含药物的水（对照组）；饮用氯化铵、碳酸氢钠或抗坏血酸的大鼠；最后是膀胱乙状结肠间置术大鼠。仅在肠间置术组中癌症发病率显著降低（p小于0.001）。抗坏血酸和改变的尿液pH值并无预防作用。文中讨论了可能的机制。