输尿管乙状结肠吻合术致癌的大鼠模型
Rat model for carcinogenesis in ureterosigmoidostomy.
作者信息
Crissey M M, Steele G D, Gittes R F
出版信息
Science. 1980 Mar 7;207(4435):1079-80. doi: 10.1126/science.7355272.
PMID:7355272
Abstract
A rat model is used to study the carcinogenesis that occurs when urine is surgically diverted into the fecal stream, as in ureterosigmoidostomy. Adenocarcinoma of the colon occurs adjacent to the urine inlet. It is completely prevented by proximal diversion of the feces, implying that fecal carcinogens are activated locally by the urine or the urothelium.
摘要
采用大鼠模型研究输尿管乙状结肠吻合术等将尿液手术改道至粪便流中时发生的致癌作用。结肠腺癌发生在尿液入口附近。粪便近端改道可完全预防该癌症，这意味着粪便致癌物被尿液或尿路上皮局部激活。
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