Fell J T, Efentakis E
J Pharm Pharmacol. 1978 Sep;30(9):538-41. doi: 10.1111/j.2042-7158.1978.tb13319.x.
The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol has been assessed using methanol--water mixtures to give a range of surface tensions. The results have been interpreted in terms of the critical surface tension, adhesion tension and spreading coefficients. The critical surface tension values are surprisingly low which may be due to adsorption of the methanol at the solid surface, exposing its CH3 group to the liquid. The adhesion tension and spreading coefficient values could be useful guides in formulation.
已使用甲醇 - 水混合物来提供一系列表面张力，以此评估乙酰水杨酸、水杨酸、非那西丁和扑热息痛粉末的润湿性。已根据临界表面张力、粘附张力和铺展系数对结果进行了解释。临界表面张力值出奇地低，这可能是由于甲醇在固体表面吸附，使其-CH₃基团暴露于液体中所致。粘附张力和铺展系数值在配方设计中可能是有用的指导。
