Buckton G, Newton J M
J Pharm Pharmacol. 1985 Sep;37(9):605-9. doi: 10.1111/j.2042-7158.1985.tb05094.x.
The use of a technique involving the assessment of the rate of penetration of a liquid into powder beds has been critically evaluated as a method for characterizing the wetting and surface energy of a hydrophobic powder (amylobarbitone). The choice of the perfect wetting liquid has been assessed, and the possible use and value of extrapolation techniques to indicate the theoretical result for water have been explored. Values of 99.5 and 102.8 obtained for the contact angle, and 25.7 and 26.9 mNm-1 for the critical surface energy, were the best estimates obtainable by this technique. Previously reported limitations of the Washburn equation have been considered.
一种涉及评估液体渗透到粉末床速率的技术已被严格评估，作为一种表征疏水性粉末（戊巴比妥）润湿性和表面能的方法。已评估了理想润湿液的选择，并探讨了外推技术用于指示水的理论结果的可能用途和价值。通过该技术可获得的最佳估计值为接触角99.5和102.8，临界表面能为25.7和26.9 mN/m。已考虑了先前报道的沃什伯恩方程的局限性。
