Fouda Abdel-Motaal M, Bazeed Anees M
Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
New Mansoura General Hospital, Mansoura, Egypt.
Drug Saf Case Rep. 2017 Oct 31;4(1):14. doi: 10.1007/s40800-017-0059-7.
In this report we address an unusual adverse effect of finasteride (Propecia 1 mg tablets) that was associated with painless hematuria and hematospermia in a 38-year-old healthy male during treatment of androgenic alopecia at a dose of 1 mg/day. It was found that the bleeding was linked to finasteride use as it occurred 2-3 days after use and stopped upon discontinuation of the drug. The patient was subjected to urological examination, laboratory investigations, and radiological imaging to identify the probable cause of bleeding. It appeared the bleeding was most probably of prostatic origin in the absence of obvious underlying pathology. The frequency of such unusual bleeding remains to be investigated in large clinical trials to address its exact mechanism, predisposing factors, clinical significance, and potential long-term consequences.
在本报告中，我们阐述了非那雄胺（保法止1毫克片剂）一种不寻常的不良反应，该反应发生在一名38岁健康男性身上，他在以每日1毫克的剂量治疗雄激素性脱发期间出现无痛性血尿和血精。发现出血与使用非那雄胺有关，因为出血发生在用药后2 - 3天，停药后出血停止。对该患者进行了泌尿外科检查、实验室检查和影像学检查，以确定出血的可能原因。在没有明显潜在病理状况的情况下，出血似乎最有可能源于前列腺。这种不寻常出血的发生率仍有待在大型临床试验中进行研究，以阐明其确切机制、诱发因素、临床意义及潜在的长期后果。
