Seo Ji-Hyun, Chung Hye Jin, Kim Hye-Jung, Yeom Jung Sook, Park Ji Sook, Park Eun-Sil, Lim Jae-Young, Park Chan-Hoo, Woo Hyang-Ok, Youn Hee-Shang, Park Jun-Je
Departments of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science, Jinju, Korea.
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Korea.
Turk J Pediatr. 2016;58(6):616-622. doi: 10.24953/turkjped.2016.06.007.
Serum concentrations of 25-hydroxy vitamin D < sub > 3 < /sub > [25(OH)D3] and vitamin D deficiency have changed over time in Korean children. This study assessed serum 25(OH)D3 concentrations and the prevalence of vitamin D deficiency in children. Serum samples were obtained during 1995 to 2011, and 25(OH)D3 concentrations were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Tests of 948 serum samples showed that median 25(OH)D < sub > 3 < /sub > concentrations decreased significantly (P < 0.001), and the rates of vitamin D deficiency/insufficiency increased significantly (P < 0.001), over 15 years. Median serum 25(OH)D < sub > 3 < /sub > was significantly higher in males than in females in 2005-2006 and 2010-2011 (P < 0.001), whereas the rates of vitamin D deficiency/insufficiency were higher in subjects aged 11-15 years than in the other two age groups after the year 2000. These increases over time in vitamin D deficiency/insufficiency may be due to the changing lifestyles of children. Outdoor physical activity should be strongly encouraged.
韩国儿童血清25-羟基维生素D3[25(OH)D3]浓度及维生素D缺乏情况随时间发生了变化。本研究评估了儿童血清25(OH)D3浓度及维生素D缺乏的患病率。在1995年至2011年期间采集血清样本，采用液相色谱-串联质谱法（LC-MS/MS）测定25(OH)D3浓度。对948份血清样本的检测显示，在15年期间，血清25(OH)D3浓度中位数显著下降（P<0.001），维生素D缺乏/不足率显著上升（P<0.001）。在2005 - 2006年和2010 - 2011年，男性血清25(OH)D3中位数显著高于女性（P<0.001），而在2000年后，11 - 15岁受试者的维生素D缺乏/不足率高于其他两个年龄组。维生素D缺乏/不足随时间的这些增加可能归因于儿童生活方式的改变。应大力鼓励户外体育活动。
