Oliveira Renato de, Cabral Fernanda Godoy, Carvalho Waldemar de Almeida Pereira, Cordts Emerson Barchi, Bianco Bianca, Barbosa Caio Parente
Instituto Ideia Fértil, Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
Einstein (Sao Paulo). 2017 Jul-Sep;15(3):273-277. doi: 10.1590/S1679-45082017AO4091.
To evaluate the predictive capacity for pregnancy of the progesterone level on the day of administering human chorionic gonadotropin, in women submitted to assisted reproductive techniques.
An observational study with 914 women submitted to assisted reproductive techniques from August 2014 to June 2016.
Total pregnancy rate was 34.58%; in that, the pregnancy rate in women <35 years, between 35 and 38, and >38 years was, respectively, 42.3%, 38.7% and 16.1% (p<0.001). For embryo transfer in the same cycle, and progesterone of 1.3ng/dL, sensitivity was 4.78%, specificity, 84.18%, accuracy, 56.72%, positive likelihood ratio of 0.3019, and negative likelihood ratio of 1.1312, with receiver operating characteristic curve of 0.46 (95%CI: 0.42-0.49).
The progesterone level on the day of administering human chorionic gonadotropin of 1.3ng/dL differs from that empirically adopted at the study site (1.7ng/dL), and has a better predictive capacity for pregnancy in the patients studied. However, the low sensitivity of this examination raises questions about its real importance.
评估接受辅助生殖技术的女性在注射人绒毛膜促性腺激素当天的孕酮水平对妊娠的预测能力。
对2014年8月至2016年6月期间接受辅助生殖技术的914名女性进行观察性研究。
总妊娠率为34.58%；其中，年龄<35岁、35至38岁和>38岁女性的妊娠率分别为42.3%、38.7%和16.1%（p<0.001）。对于同一周期的胚胎移植，孕酮水平为1.3ng/dL时，敏感性为4.78%，特异性为84.18%，准确性为56.72%，阳性似然比为0.3019，阴性似然比为1.1312，受试者工作特征曲线为0.46（95%CI：0.42 - 0.49）。
注射人绒毛膜促性腺激素当天孕酮水平为1.3ng/dL与研究地点经验采用的水平（1.7ng/dL）不同，且对所研究患者的妊娠具有更好的预测能力。然而，该检查的低敏感性引发了对其实际重要性的质疑。
