抗阻训练和山楂提取物可改善链脲佐菌素诱导的糖尿病大鼠的认知功能障碍。
Resistance training and hawthorn extract ameliorate cognitive deficits in streptozotocin-induced diabetic rats.
机构信息
Department of Physical Education, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Hamedan Branch, Hamedan, Iran.
Department of Physical Education and Sport Science, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran.
出版信息
Biomed Pharmacother. 2018 Jan;97:503-510. doi: 10.1016/j.biopha.2017.10.138. Epub 2017 Nov 6.
It has been shown that diabetic rats display cognitive impairment. The aim of this study was to investigate the effects of resistance training and natural antioxidants on learning and memory in type 1 diabetic rats. For this purpose, fifty male Wistar rats were randomly divided into five groups: (i) Control (Con, n=10), (ii) Diabetic (D, n=10), (iii) Diabetic+Resistance training (DRT, n=10), (iv) Diabetic+natural antioxidants (DHE, n=10), and (v) Diabetic+Resistance training+ natural antioxidants (DRH, n=10). Climbing the ladder for a period of 5days/week for 10 consecutive weeks was considered as the resistance training model in our study. Natural antioxidants (100mg/kg per day) were administered to natural antioxidant groups for a period of 10 weeks. Moreover, spatial and passive avoidance learning and memory function were evaluated by Morris Water Maze (MWM) and shuttle box tests. The results showed that, mean of total escape latency decreased 25% (P<0.0001) in the DRH group compared with the D group in MWM. The percentage of time spent in the target quadrant identically decreased (34%) in the D and DHE groups compared with the Con group (p=0.001). In this regard, time spent in the dark Compartment (TDC) respectively rose 86% and 95% in the D and DHE groups compared with the Con group (p<0.05), and decreased 88% in the DRT and DRH groups compared with the D group in the shuttle box test (p<0.05). Furthermore, we noticed that total antioxidant capacity increase and lipid peroxidation decrease in response to the treatments in the diabetic rats as well. Therefore, the current study indicated that exercise training and natural antioxidants synergistically ameliorated learning and memory deficits in type 1 diabetic rats via reducing oxidative stress. Hence, it may propose a potential role of resistance training and natural antioxidants as an adjuvant therapy for the prevention and treatment of diabetic complications.
已经表明，糖尿病大鼠表现出认知障碍。本研究的目的是研究阻力训练和天然抗氧化剂对 1 型糖尿病大鼠学习和记忆的影响。为此，将 50 只雄性 Wistar 大鼠随机分为五组：（i）对照组（Con，n=10），（ii）糖尿病组（D，n=10），（iii）糖尿病+阻力训练组（DRT，n=10），（iv）糖尿病+天然抗氧化剂组（DHE，n=10）和（v）糖尿病+阻力训练+天然抗氧化剂组（DRH，n=10）。我们的研究中，将每周 5 天连续 10 周爬上梯子作为阻力训练模型。天然抗氧化剂（每天 100mg/kg）给予天然抗氧化剂组 10 周。此外，通过 Morris 水迷宫（MWM）和穿梭箱测试评估空间和被动回避学习和记忆功能。结果表明，与 D 组相比，DRH 组在 MWM 中的总逃避潜伏期平均减少了 25%（P<0.0001）。D 和 DHE 组在目标象限花费的时间百分比与 Con 组相比相同（减少了 34%）（p=0.001）。在这方面，D 和 DHE 组在黑暗隔间（TDC）中花费的时间分别比 Con 组增加了 86%和 95%（p<0.05），DRT 和 DRH 组与 D 组相比，在穿梭箱测试中，DRT 和 DRH 组的 TDC 分别减少了 88%（p<0.05）。此外，我们还注意到，糖尿病大鼠的总抗氧化能力增加和脂质过氧化减少对这些治疗有反应。因此，本研究表明，运动训练和天然抗氧化剂通过减轻氧化应激协同改善 1 型糖尿病大鼠的学习和记忆障碍。因此，它可能提出了阻力训练和天然抗氧化剂作为预防和治疗糖尿病并发症的辅助治疗的潜在作用。
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