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Studies on DNA binding of caffeine and derivatives: evidence of intercalation by DNA-unwinding experiments.

作者信息

Tornaletti S, Russo P, Parodi S, Pedrini A M

机构信息

Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Pavia, Italy.

出版信息

Biochim Biophys Acta. 1989 Jan 23;1007(1):112-5. doi: 10.1016/0167-4781(89)90138-3.

DOI:10.1016/0167-4781(89)90138-3
PMID:2909237
Abstract

Caffeine and derivatives are compounds with pleiotropic effects on the genetic material which are supposed to originate from drugs binding to DNA. Here we show, by using two different topological methods, that methylated oxypurines, at biologically relevant concentrations, unwind DNA in a fashion similar to known intercalators. Methylated oxypurines could be ranked by decreasing unwinding potency: 8-methoxycaffeine greater than 8-ethoxycaffeine greater than 8-chlorocaffeine greater than caffeine greater than theophylline. These findings confirm, with a different assay, interaction of caffeine with DNA and add additional support to an intercalative mode of binding of these drugs to DNA.

摘要

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Studies on DNA binding of caffeine and derivatives: evidence of intercalation by DNA-unwinding experiments.
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