Xu Hong-Bo, Yang Tong-Hua, Xie Pei, Liu Shi-Jun, Liang Yan-Ni, Zhang Yu, Song Zhong-Xing, Tang Zhi-Shu
a Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research , Shaanxi University of Chinese Medicine , Xianyang , P.R. China.
b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , P.R. China.
Nat Prod Res. 2018 May;32(9):1088-1094. doi: 10.1080/14786419.2017.1380019. Epub 2017 Nov 2.
A new pheophytin, (13S, 17S, 18S)-13-hydroxy-20-chloro-ethylpheophorbide a (3), along with two known analogues (1-2) were isolated from the lichen Usnea diffracta Vainio (Parmeliaceae). Among them, compound 3 was a rare C-20-chloro type pheophytin obtained from lichens. Their structures were elucidated by extensive spectroscopic analysis, and all the compounds were obtained for the first time from U. diffracta. Compounds (1-3) were evaluated for their xanthine oxidase (XO) inhibitory activities in vitro, and the results showed that 1-3 possessed significant enzyme inhibitory actions with IC values of 46.9 ± 3.8, 75.9 ± 7.4 and 42.1 ± 1.7 μg/mL, respectively.
从地衣松萝（梅衣科）中分离出一种新的脱镁叶绿素，即(13S, 17S, 18S)-13-羟基-20-氯-乙基脱镁叶绿酸a（3），以及两种已知类似物（1-2）。其中，化合物3是从地衣中获得的一种罕见的C-20-氯型脱镁叶绿素。通过广泛的光谱分析阐明了它们的结构，并且所有化合物均首次从松萝中获得。对化合物（1-3）进行了体外黄嘌呤氧化酶（XO）抑制活性评估，结果表明1-3具有显著的酶抑制作用，IC值分别为46.9±3.8、75.9±7.4和42.1±1.7μg/mL。
