Waxman K, Eloi L, Dinh L, Scannell G, Tominaga G T
Department of Surgery, University of California Irvine Medical Center, Orange 92668.
Resuscitation. 1993 Dec;26(3):237-42. doi: 10.1016/0300-9572(93)90144-f.
Pentoxifylline (PTX) and superoxide dismutase (SOD) have each proven effective in improving survival when administered during resuscitation in animal models of hemorrhagic shock. This study was conducted to determine if PTX and SOD combined would have synergistic effectiveness in the treatment of hemorrhagic shock. Sprague-Dawley rats (n = 40) were phlebotomized at 25 ml/kg for 2 min, then subjected to a 45-min ischemic period, and resuscitated with lactated Ringer's solution (LR) (50 ml/kg) over 1 h. This model resulted in 70% mortality over 72 h when resuscitation was with LR alone. Animals were randomized into groups to receive one of the following agents during resuscitation: PTX in LR, SOD in LR, a combination of PTX and SOD in LR, or LR alone. PTX or SOD alone were effective in prolonging survival. However, the combination of PTX and SOD did not prolong survival above LR control.
己酮可可碱（PTX）和超氧化物歧化酶（SOD）在失血性休克动物模型复苏过程中给药时，各自都已被证明对提高生存率有效。进行本研究以确定PTX和SOD联合使用在治疗失血性休克中是否具有协同效果。将40只Sprague-Dawley大鼠按25 ml/kg放血2分钟，然后经历45分钟缺血期，再用乳酸林格氏液（LR）（50 ml/kg）在1小时内进行复苏。当单独用LR复苏时，该模型在72小时内死亡率为70%。动物被随机分组，在复苏期间接受以下药物之一：LR中的PTX、LR中的SOD、LR中的PTX和SOD组合或单独的LR。单独使用PTX或SOD可有效延长生存期。然而，PTX和SOD的组合并未使生存期延长超过LR对照组。
